SAN DIEGO (AP) -- Cory Spangenberg's first big league home run came on the first pitch he saw as a pinch hitter with one out in the ninth inning and gave the San Diego Padres a 2-1 victory against the Arizona Diamondbacks on Tuesday night.
Spangenberg, hitting for Cameron Maybin, connected against Brad Ziegler (5-3), sending a drive to the home run porch down the right-field line at Petco Park.
Spangenberg made his big league debut on Monday, hitting a two-run single and making two nice plays at third base.
Kevin Quackenbush (3-3) pitched the ninth for the win.
The Padres had runners on first and third and no outs in the eighth before Evan Marshall struck out the side.
Rookie Odrisamer Despaigne again pitched well at Petco Park but didn't get the decision. The Cuban right-hander allowed one run and four hits in seven innings. He retired 11 straight after Miguel Montero's RBI single in the fourth.
The Diamondbacks had three of their four hits against Despaigne in the fourth. Cliff Pennington and David Peralta singled before Mark Trumbo struck out. Montero then singled to center to bring in Pennington.
Despaigne has a 2.11 ERA in seven home starts while his ERA in six road starts is 4.45.
Arizona's Wade Miley had a similar line to Despaigne, allowing one run and seven hits in seven innings.
San Diego tied it in the fifth when it got three hits against Miley, including Alexi Amarista's run-scoring single to left.
In his last five starts, Miley is 0-2 with a 2.20 ERA after getting just six runs of support.
Diamondbacks: Reinstated OF A.J. Pollock (fractured right hand) and INF Chris Owings (strained left shoulder) from the 15-day disabled list.
Padres: Among their many moves was recalling INF Ryan Jackson from Triple-A El Paso and placing him on the 60-day disabled list with a right wrist strain.
Diamondbacks: RHP Josh Collmenter (9-7, 3.94 ERA) looks to beat Padres again. He's 2-0 with a 0.66 ERA in two starts against San Diego this year.
Padres: RHP Andrew Cashner (2-6, 2.37 ERA) has not factored in the decision in his two starts since coming off his second stint on the disabled list.