AP Top News at 10:46 p.m. EDT

Trump's open path to nomination causes agony for some in GOP
WASHINGTON (AP) - Donald Trump's last Republican foe, Ohio Gov. John Kasich, ended his quixotic presidential campaign Wednesday, cementing Trump's remarkable triumph as his party's presumptive nominee and launching him toward a likely fall battle with Hillary Clinton. Some Republican leaders began reluctantly rallying around Trump, but others agonized over their party's future. The billionaire businessman vowed to unite the splintered GOP, even as he was bitingly dismissive of members who have been critical of his campaign. "Those people can go away and maybe come back in eight years after we served two terms," he said on NBC's "Today" Show. "Honestly, there are some people I really don't want." Trump's challenge in uniting Republicans was abundantly clear Wednesday.

US government: North Carolina LGBT law violates civil rights
RALEIGH, N.C. (AP) - A North Carolina law limiting protections to LGBT people violates federal civil rights laws and can't be enforced, the U.S. Justice Department said Wednesday, putting the state on notice that it is in danger of being sued and losing hundreds of millions of dollars in federal funding. The law, which requires transgender people to use public bathrooms that conform to the sex on their birth certificate, has been broadly condemned by gay-rights groups, businesses and entertainers. Some have relocated offices or canceled shows in the state. Several other states have proposed similar laws in recent months limiting protections to lesbian, gay, bisexual and transgender people.

10 Things to Know for Thursday
Your daily look at late-breaking news, upcoming events and the stories that will be talked about Thursday: 1. OHIO GOV. JOHN KASICH ENDS HIS QUIXOTIC PRESIDENTIAL CAMPAIGN The move underscores Donald Trump's remarkable rise as the presumptive GOP nominee and likely pits him against Hillary Clinton. 2. WHO SIPPED THE WATER IN FLINT Obama. He promises to ride herd on leaders at all levels of government until every drop of water flowing into homes in the Michigan town is safe to use. 3. THE JUSTICE DEPARTMENT PUT WHICH STATE ON NOTICE AND WHY The DOJ says North Carolina risks being sued and losing federal funding because a state law limiting protections to LGBT people violates civil rights laws.

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Obama tells Flint residents, 'I've got your back'
FLINT, Mich. (AP) - Sipping filtered city water to show it's again drinkable, President Barack Obama promised Wednesday to ride herd on leaders at all levels of government until every drop of water flowing into homes in Flint, Michigan, is safe to use. He also promised that the aging pipes that contaminated the water with lead will be replaced, but cautioned that the project will take time. Obama said he wanted to use the crisis to make long-term improvements to the city, where more than 40 percent of residents live in poverty. "It's not going to happen overnight, but we have to get started," Obama told hundreds of people gathered in a high school gymnasium.

US declares Aleppo cease-fire, Syria says only for 48 hours
DAMASCUS, Syria (AP) - Sporadic violence persisted in Aleppo on Wednesday as U.S. officials announced an agreement had been reached with Russia to extend Syria's fragile cease-fire to the deeply contested northern city. The Syrian military said the truce would last only 48 hours. Restoration of a partial truce would bring relief to residents on both sides of Syria's largest city after two weeks of relentless violence that has killed nearly 300 people, destroyed hospitals and brought it to the brink of humanitarian disaster. It was not immediately clear whether the new effort will be observed or for how long. The U.S.

Questions: Did Prince's call for help get right response?
CHICAGO (AP) - Dramatic details emerging about how a California doctor reacted to a desperate call for help from Prince's staff a day before the musician was found dead have drawn criticism from experts in addiction medicine. Prince's representatives contacted Dr. Howard Kornfeld of California on April 20, with the musician's knowledge, seeking help for Prince's addiction to painkillers, Kornfeld's attorney, William Mauzy, said Wednesday. Kornfeld wasn't able to travel immediately to Minnesota, so he arranged for his son Andrew to travel instead via an overnight flight, Mauzy said. Andrew Kornfeld was carrying a small amount of the prescription drug buprenorphine.

Attorney: Prince arranged to meet addiction doctor
MINNEAPOLIS (AP) - In his final weeks, Prince hid signs of trouble from his fans, stonewalling reports of an overdose that required an emergency plane landing and making a brief public appearance to reassure them. But privately, the superstar was in crisis, seeking help from a prominent addiction expert that ultimately came too late. The day before he died, Prince's representatives reached out to a prominent California doctor who specializes in treating addiction and set up an initial meeting between the two, the doctor's Minneapolis attorney, William Mauzy, said Wednesday. He said the doctor, Howard Kornfeld, couldn't leave right away so he sent his son, Andrew, who flew out that night.

Complaint details kidnapping death of girl on Navajo nation
SHIPROCK, N.M. (AP) - On the far side of a desert hilltop in the shadow of the Shiprock Pinnacle, a towering monolith sacred to the Navajo Nation, the stranger ignored the cries of an 11-year-old girl. Hours had passed since the man had talked the girl and her brother into his van by promising to show them a movie. She begged to be taken home, but he led her away from her 9-year-old brother, to an even more remote spot, where he removed her clothes and sexually assaulted her. Then he hit her twice in the head with a tire iron and left her for dead before driving off and leaving the boy as well, all alone, as night fell.

Alberta declares emergency as fires threaten Canada oil town
FORT MCMURRAY, Alberta (AP) - Alberta declared a state of emergency Wednesday as crews frantically held back wind-whipped wildfires that have already torched 1,600 homes and other buildings in Canada's main oil sands city of Fort McMurray, forcing more than 80,000 residents to flee. Alberta Premier Rachel Notley said fire had destroyed or damaged an estimated 1,600 structures. Flames are being kept from the downtown area thanks to the "herculean'" efforts of firefighters, said Scott Long of the Alberta Emergency Management Agency. No injuries or fire related fatalities have been reported. The fire appeared near the airport late Wednesday where crews were onsite.

Denial, bargaining, acceptance: stages of a Trump candidacy
In the beginning, many took it as a joke: A billionaire developer, riding his gilded escalators down from his Manhattan penthouse, his third wife at his side, to announce he was running for president. Neil Young's "Rockin' in the Free World" blared from the speakers. No way could Donald Trump eclipse the seriously wonky political heir Jeb Bush or the fresh-faced Gen Xer Marco Rubio. "It was funny then, but I always had a little bit of dread," said Kiesha Garrison, a 36-year-old wife and mother living in Bellevue, Washington. "There were so many people saying they wanted to run for president.